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Within the earlier research, squalene is proven to reduce MPO while increasing HO-step one gene phrase inside person neutrophils and monocytes addressed with LPS. MPO is actually a human healthy protein found generally in the neutrophil azurophilic granules and you can monocyte lysosomes [85, 86, 87]. The outcome show that immediately after 18 h from procedures which have fifty M squalene, the fresh mRNA level of MPO inside LPS-handled person monocytes and you will neutrophils diminished (P 0.001).
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